ChloroquineV1, France, Analysis, bibRecord, 000099

New 3-substituted-2,1-benzisoxazoles: Synthesis and antimicrobial activities

Identifieur interne : 000099 ( France/Analysis ); précédent : 000098; suivant : 000100

New 3-substituted-2,1-benzisoxazoles: Synthesis and antimicrobial activities

Auteurs : Aida Chaker [France] ; Ennaji Najahi [France] ; Olivier Chatriant [France] ; Alexis Valentin [France] ; Nathan Téné [France] ; Michel Treilhou [France] ; Fakher Chabchoub [Tunisie] ; Françoise Nepveu [France]

Source :

Arabian Journal of Chemistry [ 1878-5352 ] ; 2017-05.

RBID : Hal:hal-02417861

English descriptors

mix :
- 1-Benzisoxazole, 2, Anthranil, Antimicrobial, Antiplasmodial.

Abstract

A new series of 3-substituted-2,1-benzisoxazoles (anthranils) were prepared by different methods and characterized by spectroscopic methods and mass spectrometry. These 2,1-benzisox-azoles were tested in vitro for their antiplasmodial activity on a chloroquine-resistant strain of Plasmodium falciparum (P.f.) (FcB1), and for antimicrobial activity against representative bacterial and fungal strains, as well as for cytotoxicity on MCF7 human breast cancer cells. Given the log P calc and selectivity index values (cytotoxicity/antiplasmodial activity ratio), the benzo[c]isoxazol-3-ylmethylene-phenyl-amine (11) (imino-benzisoxazole) was identified as the best hit against P.f. (FcB1), and the benzo[c]isoxazol-3-yl-phenyl-methanone (3) (3-acyl-2,1-benzisoxazole) against P.f. and the Geotrichum candidum fungal strain.

Url:

https://hal.archives-ouvertes.fr/hal-02417861

DOI: 10.1016/j.arabjc.2013.09.011

Affiliations:

France, Tunisie

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000171
to stream Hal, to step Curation: 000171
to stream Hal, to step Checkpoint: 000057
to stream Main, to step Merge: 000C71
to stream Main, to step Curation: 000C71
to stream Main, to step Exploration: 000C71
to stream France, to step Extraction: 000099

Links to Exploration step

Hal:hal-02417861

Le document en format XML

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<idno type="DOI">10.1016/j.arabjc.2013.09.011</idno>
<series><title level="j">Arabian Journal of Chemistry</title>
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<front><div type="abstract" xml:lang="en">              <p>A new series of 3-substituted-2,1-benzisoxazoles (anthranils) were prepared by different methods and characterized by spectroscopic methods and mass spectrometry. These 2,1-benzisox-azoles were tested in vitro for their antiplasmodial activity on a chloroquine-resistant strain of Plasmodium falciparum (P.f.) (FcB1), and for antimicrobial activity against representative bacterial and fungal strains, as well as for cytotoxicity on MCF7 human breast cancer cells. Given the log P calc and selectivity index values (cytotoxicity/antiplasmodial activity ratio), the benzo[c]isoxazol-3-ylmethylene-phenyl-amine (11) (imino-benzisoxazole) was identified as the best hit against P.f. (FcB1), and the benzo[c]isoxazol-3-yl-phenyl-methanone (3) (3-acyl-2,1-benzisoxazole) against P.f. and the Geotrichum candidum fungal strain.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Tunisie</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Chaker, Aida" sort="Chaker, Aida" uniqKey="Chaker A" first="Aida" last="Chaker">Aida Chaker</name>
</noRegion>
<name sortKey="Chatriant, Olivier" sort="Chatriant, Olivier" uniqKey="Chatriant O" first="Olivier" last="Chatriant">Olivier Chatriant</name>
<name sortKey="Najahi, Ennaji" sort="Najahi, Ennaji" uniqKey="Najahi E" first="Ennaji" last="Najahi">Ennaji Najahi</name>
<name sortKey="Nepveu, Francoise" sort="Nepveu, Francoise" uniqKey="Nepveu F" first="Françoise" last="Nepveu">Françoise Nepveu</name>
<name sortKey="Tene, Nathan" sort="Tene, Nathan" uniqKey="Tene N" first="Nathan" last="Téné">Nathan Téné</name>
<name sortKey="Treilhou, Michel" sort="Treilhou, Michel" uniqKey="Treilhou M" first="Michel" last="Treilhou">Michel Treilhou</name>
<name sortKey="Valentin, Alexis" sort="Valentin, Alexis" uniqKey="Valentin A" first="Alexis" last="Valentin">Alexis Valentin</name>
</country>
<country name="Tunisie"><noRegion><name sortKey="Chabchoub, Fakher" sort="Chabchoub, Fakher" uniqKey="Chabchoub F" first="Fakher" last="Chabchoub">Fakher Chabchoub</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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New 3-substituted-2,1-benzisoxazoles: Synthesis and antimicrobial activities

New 3-substituted-2,1-benzisoxazoles: Synthesis and antimicrobial activities

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